Big 12 Football Week 4 Opening Lines Announced

Posted on September 19, 2022

The time has finally arrived for conference play to truly begin in the Big 12 as the nonconference schedule is nearly over and several teams are set to kickoff their conference slate this weekend.

Nine of ten teams in the conference will be in action this week, minus Oklahoma State, who is on a BYE week after dismantling Arkansas-Pine Bluff in a tune-up game this past Saturday.

Six teams will play a Big 12 opponent this week, while three others will finish up their nonconference schedules. We will get a chance to see how Vegas starts to view the hierarchy of the conference with its lines in conference play, which we will share with you, courtesy of BetOnline.

In the first game of the weekend, West Virginia will head to Blacksburg to take on the Virginia Tech Hokies on Thursday night in prime time. The Mountaineers, coming off a decisive 65-7 victory over Towson, are a three-point favorite on the road.

Three games will kickoff in the 11:00 a.m. window on Saturday, and each one of them has an intrigue of its own. First, we have the 17th-ranked Baylor Bears hitting the road to take on an undefeated Iowa State team in Ames. While it may comes as a surprise to some, the Cyclones are favored by 2.5-points in this game over Baylor, who was picked to win the conference before the season started.

Next, Sonny Dykes and the TCU Horned Frogs will head across the Dallas Metroplex to take on the SMU Mustangs. A year ago, Dykes was on the opposite sideline in this game and in this one it appears he will have a dogfight on his hands. As things sit now, this game is a pick’em.

In a battle of undefeated basketball bluebloods, the Duke Blue Devils will head to Lawrence to take on Kansas and second-year head coach Lance Leipold. The Jayhawks have a special quarterback in Jalon Daniels, and he has made quite the difference for KU offensively. That is part of the reason why Kansas is currently a nine-point favorite in this game.

In the 2:30 p.m. window, we have the No. 22 Texas Longhorns hitting the road to take on the Texas Tech Red Raiders. Although they dismantled the Red Raiders in Austin last season, winning 70-35, Vegas sees this game being much closer with UT only favored by six points.

Finally, in the 7:00 p.m. window on Saturday night, No. 6 Oklahoma will host Kansas State. Coming off a home loss to Tulane, the Wildcats are 13-point underdogs this week as the Sooners return home from a successful road trip to Lincoln.

Here is a quick look at all of the Big 12 lines at BetOnline for this weekend.